The cytotoxicity of seven Teucrium species, a long time ago used as a food spices, for beverages and teas preparing, as well as therapeutics for digestive and respiratory diseases, were examined against human cervix adenocarcinoma HeLa,... more
The cytotoxicity of seven Teucrium species, a long time ago used as a food spices, for beverages and teas preparing, as well as therapeutics for digestive and respiratory diseases, were examined against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human chronic myelogenous leukemia K562 and human breast adenocarcinoma MDA-MB-361 cells. MTT assay was used for determination of target cell survival. The most prominent cytotoxic effect was observed against K562 cells, especially by T. scordioides, T. montanum and T. botrys. All Teucrium extracts showed good cytotoxic activity on HeLa cells, but very low cytotoxic effect on MDA-MB-361 cells. In addition, the cytotoxic activities of T. scordioides and T. montanum extract were tested on healthy resting and phytohaemagglutinin-stimulated peripheral blood mononuclear cells (PHA-stimulated PBMC). T. scordioides and T. montanum extracts at concentration of 200 µg/ml reduced the resting PBMC and PHA-stimulated PBMC survival up to 10% and 20%, while the reduction of K562 cell survival at the same concentration of extracts was 94% and 97%, respectively. These results point to selectivity in their antitumor actions. Teucrium species can be regarded as promising candidates for natural plant sources of effective biological compounds as a supplements in the food industry, as well as for therapeutic use.
Cited By (since 1996):3, Export Date: 18 October 2014
The aim of this study was to investigate the antioxidant activity of the methanolic extracts of Filipendula hexapetala Gilib. aerial parts (FHA) and roots (FHR) and their potential in different model systems, as well as antimicrobial... more
The aim of this study was to investigate the antioxidant activity of the methanolic extracts of Filipendula hexapetala Gilib. aerial parts (FHA) and roots (FHR) and their potential in different model systems, as well as antimicrobial activity. According to this, a number of assays were employed to evaluate the antioxidant and antimicrobial potential of F. hexapetala extracts. In addition, the antioxidant activity assays in different model systems were carried out, as well as pH, thermal and gastrointestinal stability studies. The phenolic compounds contents in FHA and FHR were also determined. The results showed that F. hexapetala extracts had considerable antioxidant activity in vitro and a great stability in different conditions. The extracts exhibited antimicrobial activity against most of the tested bacterial and fungal species. Also, the extracts contain high level of phenolic compounds, especially aerial parts extract.
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Research Interests: Water, Free Radicals, Pain, Plant Biology, Inflammation, and 24 moreMedicinal Plants, Food Chemistry, Flavonoids, Multidisciplinary, Antioxidants, South Africa, Humans, Animals, Headache, Methanol, Ethanol, Comparative Analysis, Asteraceae, Clinical Sciences, Antioxidant Activity, Phenols, Phenolic compound, Plant extracts, Fabaceae, Acetone, Oxidation-Reduction, Total Phenolic Content, Abies, and Plant Leaves
Agent-based systems are one of the most important and exciting areas of research and development that emerged in information technology (IT) in the past two decades. In a nutshell, an agent is a computer program that is capable of... more
Agent-based systems are one of the most important and exciting areas of research and development that emerged in information technology (IT) in the past two decades. In a nutshell, an agent is a computer program that is capable of performing a flexible, autonomous action in typically dynamic and unpredictable domains (Luck, McBurney, Shehory, & Willmott, 2005).